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KMID : 0382619910110010451
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Hanyang Journal of Medicine
1991 Volume.11 No. 1 p.451 ~ p.463
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Central Sensitization of the Dorsal Horn Cells during Cutaneous Inflammation
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Abstract
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To examine whether the dorsal horn neuron (DHN) can be sensitized by noxious stimuli from the receptive field (RF), the responses of DHN receiving inputs from both the cutaneous receptors and the muscle to noxious stimuli were determined in the cat with cutaneous inflammation Induced by topical application of either carrageenan (CARG) inside of or mustard oil (MO) outside of RF.
After induction of cutaneous inflammation with carrageenan the responses of DHN to noxious stimulation of the cutaneous receptors and the muscle increased respectively by 163.2±16.9% and 145.8±8.I%, while the responses increased respectively by 179.3% and 207.2±31.8% durin mustard oil-induced inflammation. When either one of the tibial nerve or the common peroneal nerve was electrically stimulated after application of mustard oil to the other nerve, A-response of DHN to single stimulus increased by 148.5± 9.2% and A-and C-responses to train siimuli enhanced by 189.1% and 194.9%, respectively. Even after MO-induced noxious input from the cutaneous receptors was blocked with lidocaine, the sensitization of DHN was sustained. As in normal animals an enhanced activity of DHN by the cutaneous inflammation was also inhibited by the remote noxious nerve stimulation.
The results indicate that cutaneous inflammation induced with CARG or MO can produce the sensitization of the cutaneous receptors and of the spinal cord as well.
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